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The average patient treated with the oral semaglutide 14 mg pathway was estimated to incur $US39,997 in direct healthcare costs (medical and pharmacy) over 5 years, compared with $US23,436 for the average patient treated with the sitagliptin 100 mg pathway, an incremental cost per patient of $US16,562 (70.7% increase) (Table 5)

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Pathway-vital target network model and analysis The network of main components and their related targets of Chinese herbal medicine FRP is shown in Figure 10, containing 182 nodes and the top 20 KEGG pathways associated with 235 targets and 553 edges

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