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The affinity, cAMP activity, and insulinotropic activity in vitro all decline when Ala 8 is substituted with Gly 8 (IC 50 : 44.9 nM220 nM;EC 50 : 0.15 nM1.11 nM)

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Lancet 397(10278):971984 Lewis KH et al (2019) Safety and effectiveness of longer-term phentermine use: clinical outcomes from an electronic health record cohort

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