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The major histocompatibility complex (MHC) region at 6p21, which express human leukocyte antigens (HLAs), was the first identified gene locus

10.1186/1475-2840-11-3 96 JoseT.InzucchiS

While randomized controlled trials offer rigorous evidence, they may not fully represent older, multimorbid, or polytreated patients seen in primary care