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Vitamin B 12 is needed to prevent anemia, since making porphyrin and heme in mitochondria for producing hemoglobin in red blood cells depends on succinyl-CoA made by vitamin B 12

2.4 Quality Assessment and Risk of Bias As there are no standard guidelines to assess the risk of bias in pharmacokinetic studies, we applied a previously reported quality rating tool [11]

Some prefer ALCAR to LC as a supplement due to its increased bio-availability, 1 meaning it is more readily absorbed from the gut, and its ability to cross the blood-brain barrier allowing it to modulate numerous functions in the brain

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As well, SIRT1 deactivates the p53 protein preventing apoptosis and cell deaths (Khanahmadi et al