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Growth hormone stimulates hepatic IGF-1 production by binding to growth hormone receptors on liver cells, triggering intracellular signaling through the JAK2/STAT5 pathway that upregulates IGF-1 gene expression

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[PubMed: 25648738] 26

While DSIP functions as a broad neuromodulator within central nervous system signaling pathways, Epitalon and Orexin represent more targeted models of circadian regulation, cellular aging processes, and arousal signaling