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You finish a cycle, you decide what comes next.

A serum proteomic study of two case-control cohorts identifies novel biomarkers for bipolar disorder

Even more specifically, rats studied predominantly by one research group in Zagreb, Croatia

Within this pathological network, mtROS and NLRP3 inflammasome activation form a critical molecular hub: mitochondrial dysfunction induces complexes I and III of the electron transport chain to generate large amounts of mtROS, which triggers NLRP3 inflammasome activation through pathways such as promoting the binding of TXNIP to NLRP3, releasing oxidized mitochondrial DNA (ox-mtDNA) as a co-activator, and modulating mitochondrial membrane potential

doi: 10.1210/er.2011-1050 80 BondeJPToftGRylanderLRignell-HydbomAGiwercmanASpanoMet al