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Detailed knowledge regarding the physiology of drug abuse-associated BBB dysfunction, with respect to TJ protein complexes, transport systems, and intracellular signaling pathways, could allow the determination of effective therapeutic interventions

In a recent study, tamoxifen-xanthene hybrid induced mitochondria-mediated apoptosis due to activation of PARP cleavage, upregulation of Bim gene expression and increase in Bax/Bcl2 ratio in MCF-7 cells [99]