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Study protocol for the St Jamess Hospital, Tallaght University Hospital, Trinity College Dublin Allied Researchers (STTAR) Bioresource for COVID-19
Based on the challenging measure of mBDNF, an alternative strategy, although not without limitations, could involve measuring total and pro-BDNF levels separately using valid and specific commercial ELISA kits, and then estimating the concentration of mBDNF by calculating the difference (total BDNF minus pro-BDNF levels)
Indeed, ALT telomeres have a relaxed telomeric chromatin configuration (compared to telomerase positive and normal cells) making them more susceptible to DNA damage and telomere elongation through ALT (Lin et al 2021
Examples: Oxymetazoline, Phenylephrine
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