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489 In addition, machine learning models can predict patients responses to specific drug combinations on the basis of their individual characteristics, such as mutation profiles and protein expression profiles, thereby providing a basis for personalized treatment

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The restraints were derived from (i) NOE restraints from intermolecular and intramolecular cross-peaks in NOESY spectra (described in NMR spectroscopy section), (ii) TALOS derived p53 TAD2 and FOXO4-DRI backbone dihedral angles, (iii) hydrogen bond restraints (regions p53 residues 4752, FOXO4-DRI residues 918

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