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Method of Dilation (Balloon, Bougie, etc.)

Glutathione GSH

Researchers at higher maintenance doses often prefer 20mg vials because they last longer and reduce the frequency of reconstitution

Author contributions All authors listed have made a substantial, direct, and intellectual contribution to the work and approved it for publication

Conclusions: Based on the evidences reviewed, this systematic review does not recommend coffee enema self-administration as a complementary and alternative medicine modality that can be adopted as a mean of self-care, given the unsolved issues on its safety and insufficient evidence with regard to the effectiveness