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Winchester, MD, MS, FACC Megan Coylewright, MD, MPH, FACC Ex Officio Table of Contents Preface 1368 1

Phentermine is generally a lower-cost option, while GLP-1 medications like semaglutide can be more expensive and have variable insurance coverage

However, a small subset of patients presents with highly aggressive or radioactive iodine-resistant forms of thyroid cancers with increasing recurrence rates of nearly 15% within 10 years 5

NICE Technology Appraisal 875 (Wegovy) and TA664 (Saxenda) recommend these treatments within specialist tier 3 or 4 weight management services for adults with a BMI of 35 kg/m or above (or 32.5 kg/m or above for people from South Asian, Chinese, other Asian, Middle Eastern, Black African or African-Caribbean family backgrounds), with weight-related comorbidities

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