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However, upon exposure to powerful pro-oxidant stimuli such as dapsone or primaquine, acute extravascular and then intravascular hemolysis can occur leading to the release of heme and free iron into the local intravascular environment 57

The messages of one hormone may start the activity of other hormones

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Recent research provided a deeper understanding of this notion, revealing that carbohydrate metabolism could adapt to the hypoxia condition in mild preeclampsia while a decompensation of carbohydrate metabolism reprogramming was discovered in severe preeclampsia (11) (Figure 2)

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