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These authors concluded that the proportion of LBM relative to total body mass increased with semaglutide. Similarly, in the SURMOUNT-1 trial which studied tirzepatide, researchers found that participants treated with tirzepatide had a percent reduction in fat mass approximately 3 times greater than the reduction in lean mass, resulting in an overall improvement in body composition. More recently, a viewpoint in JAMA re-grounded the conversation: weight loss in persons with obesity primarily reduces body fat, but also decreases fat free mass (FFM)

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Haller CA, Benowitz NL

Moser H (1987) Electrophysiological evidence for ammonium as a substitute for potassium in activating the sodium pump in a crayfish sensory neuron