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This substudy was required by the FDA to ensure the drug did not cause excessive HR increase and included 600 patients who underwent ABPM prior to randomization and again at the end of the 36-week study period

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Combining Short-Term GLP-1 Therapy with Lasting Behavioral Change The window of appetite suppression and motivation while on GLP-1 therapy creates a unique opportunity to establish new eating patterns and exercise routineshabits that must outlast the medication itself

The medium and high-dose patients also have a 4-point reduction in their BMI

10.1016/j.foodchem.2008.04.019 42 PodporaB.widerskiF.SadowskaA.PiotrowskaA.RakowskaR