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Some of these medications are commonly used in the United States (1, If you have G6PD deficiency, its important to talk with your doctor and pharmacist about which medications you should avoid or use with extra caution ( Acetaminophen: an analgesic (pain-relieving) drug Acetylsalicylic acid (aspirin): an anti-inflammatory drug Chloramphenicol: an antibiotic drug Chloroquine: an immunosuppressant and antimalarial drug Colchicine: a gout medication Diaminodiphenyl sulfone (Dapsone): an antibiotic and antimalarial drug Diclofenac sodium: an anti-inflammatory drug Diphenhydramine: an antihistamine drug Glyburide: a diabetes drug Ibuprofen: an anti-inflammatory drug Izoniazid: an antibiotic drug L-dopa: a Parkinsons disease treatment Methylene blue: a dye and blood disorder treatment Nitrofurantoin: an antimicrobial drug Phenazopyridine: an analgesic drug Primaquine: an antimalarial drug Rasburicase: a gout medication Streptomycin: an antibiotic drug Sulfa drugs: a group of antibiotics that includes co-trimoxazole, sulfacetamide, and trimethoprim Tripelennamine: an antihistamine drug Vitamin K: a dietary supplement A 2019 review also suggests caution if using herbal supplements or extracts containing Rhizoma coptidis (also called Huang Lian) or Coptis chinensis