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The compound was developed in the late 1990s by Novo Nordisk and characterised in a 1998 paper as the first selective GH secretagogue, meaning it stimulated GH release without the prolactin, ACTH, cortisol, or aldosterone elevations seen with earlier GHRPs

The latter effect is the result of the reduced ability for platelets to adhere to exposed sub-endothelial extracellular matrix collagen which is required for their activation

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Novo Nordisks blockbuster GLP-1 drug Ozempic has nabbed yet another label expansion outside of its original field, with the FDA granting approval for its use in chronic kidney disease

PLoS One 9 (1), e86301