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Data on duration of medication use, adherence, discontinuation and concomitant medications cannot be captured from prescriptions databases, and dosing data for liraglutide and dulaglutide were unavailable or incomplete, so it was not possible to determine whether patients were optimized on their baseline GLP-1 RA

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It's difficult to compare the results to those of other drugs without head-to-head studies, but the weight loss caused by Metsera's injection appears to be encouraging

Overlapping Effects: Fluid Balance and Dehydration One of the most critical areas of concern when combining spironolactone and semaglutide is fluid balance

Lilly announced that ATTAIN-3 was the third successful Phase 3 trial, triggering global regulatory submissions for obesity in 2025