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Finally, Tirzepatide is a dual GIP and GLP-1R agonist that stimulates both receptors, potentially offering greater metabolic benefits than GLP-1 agonism alone and enabling mechanistic interplay studies

The overall mechanisms of GLP-1 agonists on weight loss are predominantly through the reduction in energy intake and not on energy expenditure

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[DOI] [PMC free article] [PubMed] [Google Scholar] 161.Elkashty, O