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While a strain of Lactobacillus exerts beneficial effects in experimental necrotizing enterocolitis through modulation of TLR4 and NF-B [294], a different strain acts through TLR2 in a radiation injury model

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[3] Other common adverse effects reported during the clinical trials include back pain, upper respiratory tract infections, melanocyte naevus, decreased appetite, migraine, dizziness, weakness, fatigue, lethargy, sleepiness, hot flashes, abdominal pain, diarrhea, vomiting, flushing, development of warts, spots, and freckles, and itchy skin (between 1% and 10% of people)