Medical conditions affecting absorption warrant particular attention : Pernicious anaemia : an autoimmune condition destroying gastric parietal cells, requiring lifelong B12 injections Gastrointestinal surgery : particularly gastric bypass, gastrectomy, or terminal ileum resection Inflammatory bowel disease : Crohn's disease affecting the terminal ileum impairs absorption Coeliac disease : untreated disease damages the small intestine, reducing B12 uptake Medication use : long-term metformin therapy (MHRA safety alert) or nitrous oxide exposure Symptoms suggesting possible B12 deficiency include : persistent fatigue, weakness, paraesthesia (pins and needles) in hands or feet, glossitis (sore, red tongue), mood changes, memory problems, or unexplained anaemia
Weighing the Pros and Cons Let's summarize the potential benefits and drawbacks: Potential Benefits (Limited Evidence, Often Concurrently with Lifestyle Changes): Possible slight energy increase: Some individuals report increased energy levels, potentially improving exercise adherence
Am I a candidate for ThermiSmooth
Long-term use of certain medications such as metformin and proton pump inhibitors (PPIs) also increases the risk of B12 deficiency
PMID 16087991
