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The GSH/GSSG-Glo Assay was performed on K-562 suspension cells after treatment for one hour with menadione in the presence and absence of CellTox Green Dye

The pharmacological properties of these polysaccharides depend on their structural characteristics (Yang et al., 2019)

2020;99: e19378

Nicotinamide adenine dinucleotide phosphate (NADPH) is synthesized by four enzymes in mammalian cells, including isocitrate dehydrogenase, malic enzyme glucose-6-phosphate dehydrogenase (G6PD), and PGD

In addition to the relevance of POP conjugation cited previously, hyperglycemia and hyperinsulinemia appear to directly inhibit glutathione synthesis (GCL), and the increased production of reactive oxygen species which accompanies diabetes further depletes GSH levels