Daily oral drugs will enter the market to join Novo Nordisks oral semaglutide, Rybelsus, in a few years time, including a new group of oral GLP-1s that includes Pfizers danuglipron and Eli Lillys orforglipron (collectively known and the gliprons), with approvals likely from 2027
Patients often prefer combinations of oral medications to injectable medications
One of the biggest impact of this news is that more or more primary care physicians will start doing FIB-4 and primary screening for MASLD/MASH
Therefore, these factors should be taken into consideration and regular monitoring should be performed in these conditions while treating vitamin B12 deficiency with cyanocobalamin
Associate Editor: Diabetes Care Priyathama Vellanki, MD, Emory University, Atlanta, Georgia consultant: Takeda Pharmaceutical Company