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Post hoc mediation analysis across SURPASS-1 through SURPASS-5 found that decreases in systolic blood pressure (ranging from 1.3 mmHg to 11.5 mmHg across the tirzepatide doses) were primarily mediated through weight loss [91]

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Among these, glutathione stands out as a powerful ally, often referred to as the body's master antioxidant

(10) Similarly, Ipamorelin has been reported to exhibit some promise in influencing adipose tissue metabolism

In parallel with the distinct NRF2 activation, SOD2, one of the downstream of NRF2 for antioxidant defense, was noticeably increased in the atria of obese mice after LCA treatment (Figures 4L,M)