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These effects correlate with the dose increments: starting at 2.4 units (0.25 mg) produces minimal GI disruption, while jumping to 10 units (1.0 mg) may trigger noticeable nausea in sensitive patients

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Cardioprotection effect of Yiqi-Huoxue-Jiangzhuo formula in a chronic kidney disease mouse model associated with gut microbiota modulation and NLRP3 inflammasome inhibition

And because you're not just losing water but also critical electrolytes like sodium, potassium, and magnesium, the effects can compound