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Key Points Tumor necrosis factor (TNF) was the first cytokine to be fully validated as a therapeutic target for rheumatoid arthritis (RA) Combination therapy with an anti-TNF biologic agent plus methotrexate halts progression of joint damage in the majority of patients with RA, irrespective of the extent of destruction on baseline radiography Studies of patients with early RA receiving anti-TNF therapy show particularly favorable outcomes

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PubMed Central PMCID: PMC2019092

It is recognized for supporting energy metabolism and athletic performance due to its role in fatty acid transport and muscle recovery

Novel chemotherapeutic and renal protective effects for the green tea (EGCG): role of oxidative stress and inflammatory-cytokine signaling