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This is particularly relevant for adults over 40, whose hormonal patterns, sleep architecture, and metabolic rhythms differ meaningfully from the younger populations in most clinical trial protocols

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In particular, the cosmetically acceptable carrier can be used as an oily or oil-alcoholic lotion, water-in-oil or oil-in-water emulsion, as a cream or as milk, in the form of oil-alcoholic, oil-water or water-alcohol gels, as a stick or conditioned as an aerosol

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