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This variation is strongly associated with reduced or altered MC1R receptor function, which can impair the ability of melanocytes to respond effectively to melanocortin signaling from -MSH or peptide analogs such as Melanotan-1

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Mohammed MA, Gharib DM, Reyad HR, Mohamed AA, Elroby FA, Mahmoud HS (2021) Antioxidant and anti-inflammatory properties of alpha-lipoic acid protect against valproic acidinduced liver injury

In some embodiments, the injection is intratympanic