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After replication in epithelial cells, HSVs reach and enter neurons and establish lifelong latency in the ganglia of the peripheral nervous system (PNS) (Sun et al., 2024)

The FDA classifies it as a Category 2 bulk drug substance, noting potential safety concerns in unregulated compounding

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Limited Antioxidant Effects : Other studies have indicated that while coffee consumption may have some antioxidant effects, the specific benefits attributed to coffee enemas remain unproven