While oral bioavailability is lower than subcutaneous administration, these studies established that even high oral doses maintained excellent safety profiles, though higher doses (54 mg) were associated with increased gastrointestinal discomfort
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In the inflammatory response, the phagocytosis of macrophages can aggravate the inflammatory response, in which ROS is involved
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J Phys Chem B 110:1606616081 Pliego JR Jr, Riveros JM (2002) Gibbs energy of solvation of organic ions in aqueous and dimethyl sulfoxide solutions