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By inhibiting this interaction, FOXO4-DRI allows reactivation of the apoptotic pathway in non-proliferative senescent cells, leading to their selective elimination without damaging healthy tissue

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Nat Commun (2016) 7:11457

Besides decreased body weight and glycemia, a decrease in systolic blood pressure by 2.22 mmHg was noted across 33 clinical trials [74], thus decreasing the incidence of hypertension, one of the main risk factors involved in the development of diabetic nephropathy [75]