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In addition to the appreciable uncertainty in the benefits of treatment with respect to growth outcomes, the included studies provided no evidence for the effect of mecasermin on other consequences of SPIGFD (e.g., metabolic abnormalities or muscle weakness)
J Formos Med Assoc 117(3):178-184
Preprint at bioRxiv (2020)
Prez-FerroMRomero-BuenoFISerrano Del CastilloCMahilloIAlvearALargoRet al
Thus, these data suggest that late-life targeting of IGF-1R signaling can recapitulate effects observed in genetic models of constitutive IGF-1R haploinsufficiency on lifespan
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