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For example, tummy tucks (abdominoplasties) can specifically target loose skin left behind after significant weight loss

The resolution of this paradox likely involves dose, individual neurological vulnerability, and the difference between GLP-1 receptor activation in different nervous system compartments

Outcomes included change from baseline at week 40 in HbA1c (primary outcome) and bodyweight (secondary confirmatory outcome), evaluated through trial product estimand (no treatment discontinuation or without rescue medication) and treatment policy estimand (regardless of treatment discontinuation or rescue medication) strategies

Metabolic and non-weight goals

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