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In addition, the severe vomiting that can be induced by alcohol or that result from the complications associated with excessive ethanol ingestion lead to dehydration and decreased extracellular fluid volume, resulting in hypotension triggering a sympathetic nervous system response

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PMC 2648137

So, even under the best of circumstances, with the most potent GLP-1 drugs taken at the highest allowable dose for at least a year to obtain the full weight loss, were only looking at a 34-pound (15 kg) drop before the weight loss stops

13, 204 adults who did not take any GLP-1 based medication) with obesity and at least one diagnosed autoimmune condition