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Ernst, R., Mueller, B., Ploegh, H

In the lixisenatide-treated group, a significant increase in HR was observed only at 5 h post-dosing, and the mean HR per day remained unchanged (69.1 8.6 to 71.7 10.6 bpm

Literature search was conducted on PubMed, Scopus, Web of Science, and Embase using a combination of the keywords gut microbiota, gut microbiome, gut-brain axis, gut-kidney axis, gut-brain-kidney axis, chronic kidney disease, dysbiosis, therapy, metabolites, and neuroinflammation. Relevant studies were selected and synthesized in this narrative review

Combined with appetite suppression and increased metabolic output, retatrutide triggers deeper fat-cell depletion than single-agonist therapies