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While some studies indicate that GLP-1RAs may improve cognitive function or reduce cognitive decline, other studies suggest that their effects are limited or not statistically significant

About the AAO Innovation and Transformation Fund By building, partnering or investing, the AAO Innovation and Transformation Fund can be used to develop new products and services for orthodontists and patients and will drive non-dues revenue for the association

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The choice comes down to what kind of clinical experience you want behind your treatment

Abbreviations AHA: American Heart Association ASCVD: Atherosclerotic cardiovascular disease CI: Confidence interval CMA: A conventional meta-analysis CVD: Cardiovascular disease EASD: European Association for the Study of Diabetes ESC: European Society of Cardiology FPG: Fasting plasma glucose GLP-1RA: Glucagon-like peptide-1 receptor agonists HbA1c: Hemoglobin A1c LVEF: Left ventricular ejection fraction MACE: Major adverse cardiovascular events MD: Mean difference PRISMA: Preferred Reporting Items for Systematic Reviews and Meta-Analyses QALY: Quality-adjusted life year RCT: Randomized controlled trial RIS: Required information size RoB2: Risk of bias tool for randomized trials RR: Risk ratio SD: Standard deviation SE: Standard error SGTL-2i: Sodium-glucose co-transporter-2 inhibitors T2DM: Type 2 diabetes mellitus TAU: Treatment as usual TSA: Trial sequential analysis UTI: Urinary tract infection References Low Wang CC, Hess CN, Hiatt WR, Goldfine AB