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Description

The clinical diagnosis of PD is based on the presence of bradykinesia and at least one of three other features: muscular rigidity, resting tremor, and postural instability (Table 43-1)

[55] Bianconi E, et al

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Most events were mild to moderate and improved as the dose stabilized

Initial studies used a redox probe, which allowed a measurement of ratios, but not absolute concentrations, and measured redox state throughout the secretory pathway rather than specifically in the ER (Hwang et al , 1992)