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We refer readers to section III.C.2.c.(3).(ii) of this final rule for further discussion of this policy

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Retatrutide adds glucagon receptor agonism on top of both, which is why the obesity field treats it as a step change rather than an incremental dose tweak

The nine dinucleotide loci (CpG1, CpG2, CpG3, CpG4, CpG5, CpG6, CpG7, CpG8, CpG9) in the GSTA4 promoter region (Chr6:52,977,953-52,995,284, GRCh38/hg38) were selected for DNA methylation pyrosequencing (Figure 1)