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91 Under physiological conditions, this process plays an important role in embryonic development and tissue repair

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Thus, ER stress-induced CHAC1 expression depletes GSH, compromises GPX4 function, and promotes ferroptotic cell death ( 4.5.3 Possible role of methionine Prolonged methionine deprivation blocks CHAC1 protein synthesis by interfering with its translation, thereby inhibiting ferroptosis

Psychiatry 7 , e1137 (2017) PubMed

In addition, the ratio of all lipid peroxidation biomarkers to all lipid-associated antioxidant defenses was significantly higher in BD patients, than in both healthy controls and patients with major depressive disorder [150]