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182 Additionally, combined inactivation of RNF5 and RNF185 leads to the stabilization of F508del CFTR, suggesting that RNF5 and RNF185 cooperate in the regulation of select substrates, as exemplified by F508del CFTR

We included peer-reviewed randomized controlled trials, meta-analyses, and high-quality narrative or systematic reviews written in English that evaluated the effects of GLP-1 receptor agonists (liraglutide, semaglutide, or related analogues), as well as dual GIP/GLP-1 receptor agonists (such as tirzepatide), exercise training, or their combination on weight loss, body composition, metabolic, or cardiovascular outcomes in adults with obesity or type 2 diabetes