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Regarding clinical activity times and supervision, commenters provided CMS with information that a typical sterile compounding session for new-patient venom build requires approximately 46 minutes of direct activity, extending to up to 86 minutes when periodic tasks are included, with about 20 minutes involving physician supervision during pre-service review and sterile preparation

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(PubMed) Termanini B, Gibril F, Sutliff VE, Yu F, Venzon DJ, Jensen RT