Crenessity works by selectively blocking the CRF1 receptor to help temper excess ACTH and other adrenal androgens
Court data shows thousands of cases overall focused primarily on GI injuries (e.g., gastroparesis in ~75% of sampled claims) and vision loss (at least 110 plaintiffs), with thyroid concerns tied to a boxed warning from rodent studies
After 12 weeks, increased conversion of testosterone to the more potent androgen dihydrotestosterone, as well as improved sperm count and motility, were seen
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That framing matters for how clinicians and patients discuss the decision to restart
