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These benefits were seen in different types of heart failure, including both: reduced ejection fraction (weaker pumping) preserved ejection fraction (stiffer filling) What the FDA Approvals Reflect As evidence has grown, FDA-approved semaglutide products now include cardiovascular indications depending on the patient population: Wegovy (2.4 mg injection): approved to reduce cardiovascular risk in people with established heart disease and overweight/obesity

In 2022, the FDA added both semaglutide and tirzepatide to its drug-shortage list

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Dapagliflozin is an inhibitor of SGLT2