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In the fifties, when chemo wasnt yet widely used, high-dose B12 shots (10,000g) were given to children with a neuroblastoma tumor, every two days, for 2-3 years

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They wake up feeling remarkably refreshed since embarking on B12 shots. Vitamin B12 can have an impact on sleep in several ways: Melatonin Production: Vitamin B12 produces melatonin, a hormone that regulates the sleep-wake cycle

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However, the independent effects of vitamin B12 on IR could not be interpreted from the mentioned trials due to combination therapy