does glp 1 affect libido GLP-1 receptor agonists may dampen libido, likely through brain pathways tied to appetite and reward, though mechanisms remain unclear. Emerging data suggest serotonin receptor effects may play a role, but clinicians note GLP-1 Side Effects in Women:

These injections mimic your bodys natural GLP-1, helping you feel full, reduce hunger, and control blood sugar

GLP-1R agonists fall under two groups: human GLP-1 backbone agents and exendin-4 backbone agents

Russell-Jones D, Vaag A, Schmitz O, Sethi BK, Lalic N, Antic S, et al

This can include individuals who are sensitive to medication side effects, have experienced difficulty tolerating standard GLP-1 dose escalation, or are looking for a lower-intensity approach under medical supervision

In a Mayo Clinic study presented at an annual meeting of the Endocrine Society in July 2025, researchers found that, over 18 months, 40 postmenopausal women who combined the GLP-1 drug tirzepatide (used in Mounjaro and Zepbound) with hormone therapy lost an average of 17 percent of their body weight