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Unexpected changes discovered in the pre-symptomatic phase To identify the cellular and molecular changes induced by neurotrophin signalling deficiency, increased DA and ageing that may promote iSPN vulnerability, we examined the transcriptional profile of relevant neurons in the presence and absence of TrkB signalling at 3 months and 8 months

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At the start of the study and at its end 16 weeks later, the participants took a series of repeated trials in which they could earn money by performing a "hard" task, which involved typing with their nondominant hand, or an "easy" one, typing with their dominant hand

Recovery slows with age

Rapid generation of long noncoding RNA knockout mice using CRISPR/Cas9 technology