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[1] From this theory, we can propose that stimulating IGF-1 in skin tissue may be a potential effective treatment for regulating skin cell differentiation, improving insulin sensitivity in the skin, reducing keratinocyte proliferation, inhibiting inflammation via stimulation of IL-10 production and up-regulating sebocyte proliferation (via IGF-1 stimulation of 5-Reductase)

Calorie restriction and cancer prevention: established and emerging mechanisms

Their active center is a conserved tetramer composed of selenocysteine residues (Sec), glutamine (Gln), tryptophan and asparagine