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Their broad substrate range, including drugs and xenobiotics, and their high expression levels at the BBB, contribute a major part to CNS pharmacoresistance [75]

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And people said, We can never treat blood pressure because these drugs are awful. How did we make better drugs

This can help prevent interactions and reduce the risk of hypoglycemia

In contrast, in the FIGHT trial, liraglutide did not show any improvement in clinical stability, outcomes or biomarkers in patients with advanced heart failure and a reduced ejection fraction, suggesting no cerebrovascular or cardioprotective benefits in this group