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The activation of GIPR can directly act on adipose tissue to increase energy expenditure and drive weight loss

High level of ROS in the sperm medium causes breakdown of nuclear and mitochondrial DNA (26)

Other GLP-1 receptor agonists may be considered, as individual tolerability can vary between agents within this class

A rapid review of 25 studies similarly found that liraglutide and semaglutide reduced binge eating episodes and prevalence, with food cravings improving with semaglutide in 6 of 7 studies ( Jebeile et al., Obesity Reviews, 2026 )