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By scavenging free radicals and regenerating other antioxidants like vitamin E, CoQ10 could theoretically help protect against oxidative damage, though clinical outcome data are limited

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The most prominent changes revealed by the RNA-seq analysis include fat metabolism and stress response genes, consistent with previous transcriptomic analyses focusing on the glp-1(-) mutant 16

Its supplementation elevates NAD + , activating SIRT1 to regulate metabolism and suppress neuroinflammation ( 4.5 Limitations and future directions Limitations of the present study include incomplete recapitulation of human SAE heterogeneity by CLP and the lack of Nrf2 knockout/GSH inhibitor validation

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