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52,53 In addition, cinchonine can inhibit toll-like receptor 2- (TLR2-) and TLR4-mediated signaling cascades, and attenuate pro-inflammatory cytokine levels in high-fat diet-induced obesity mice

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Cannabinoid receptors are also activated by endogenous ligands, the en-docannabinoids, a family of endogenous arachidonic acid derivatives, including N-arachidonylethanolamide (anandamide) and the 2-arachidonoylglycerol which is synthesized by the cell membrane (Sugiura et al., 2002)

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